San Donato Hospital is an IRCCS-accredited cardiology and cardiac surgery center. It performs over 9,400 heart and blood vessel operations each year – the most in Italy. Core specialties include cardiology, cardiac surgery, arrhythmology, and rehabilitation.

• 97% success rate for cardiac surgeries, one of the highest in Europe.
• Over 3,000 children treated internationally for congenital heart defects.
• Telepresence robots allow patients to connect with doctors anytime.
• Over 20,000 coronary artery bypass and heart valve surgeries performed.
• A hotel on the clinic grounds for patient and family stays.

San Raffaele Hospital is a top European research center with Italy's IRCCS accreditation. It achieved the world's first stem cell therapy for severe combined immune deficiency. Its main specialties are oncology, neurosurgery, and cardiovascular surgery.

• Performs over 52,000 surgeries a year and treats 12,000 cancer patients.
• Equipped with 3 da Vinci robots, Gamma Knife, Cyber Knife, and PET-MRI.
• Performed the world's first intrauterine spina bifida surgery.
• The hematology unit has completed over 1,000 bone marrow transplants.
• Part of Gruppo San Donato, a network treating 5 million patients annually.

La Madonnina Clinic is a multidisciplinary hospital in central Milan, part of Italy's San Donato network. It specializes in medical check-ups, obesity treatment with intragastric balloons, and plastic surgery. The clinic has treated high-profile patients including Silvio Berlusconi and AC Milan players.

• Open-type 1.5 Tesla MRI designed for patients with claustrophobia or excess weight.
• Elipse intragastric balloon inserted endoscopically in 10 minutes with no incisions.
• Orbera-365 balloon – the world's most popular weight loss method with over 280,000 sold.
• Plastic surgeons use computer modeling to show patients their results before surgery.
• Custom menu from the on-site restaurant. Family members can stay in the same room.

IRCCS Ospedale Galeazzi – Sant'Ambrogio is Italy's first orthopedic hospital and a government-authorized research institute (IRCCS). Its core specialties include joint surgery, spine surgery, and stem cell therapy. Part of Gruppo San Donato, the country's first healthcare network.

• 91% success rate for orthopedic surgeries – the highest in Italy.
• Performs 75% of all revision orthopedic surgeries in the country.
• Uses EOS, a 3D imaging system with lower radiation than a standard X-ray.
• RE.GA.IN stem cell unit is among few in Europe with government approval for treatments.
• Listed in Newsweek's World's Best Hospitals and World's Best Specialized Hospitals.