Award-winning stereotactic and functional neurosurgeon from Turkey, working for over 30 years.
Expert in deep brain stimulation (DBS). Has provided over 850 successful DBS procedures and more than 1,350 neurosurgery procedures. Broke a Guinness World Record for the biggest number of patients after DBS gathered in one place. Was trained in Germany, Spain, Great Britain, Israel, Belgium, and the USA. Cooperates with Bookimed from 2018 and regularly trains and educates the Bookimed’s team for training and education in neurology.
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Lire la suiteGülümser Kızıltaş Tokmak, M.D., graduated from Cerrahpaşa School of Medicine, Istanbul University in 2002 and completed residency at Neurology Clinic, Okmeydanı Teaching and Research Hospital in 2008. She holds a master’s degree in Electrophysiology from Istanbul University, and has studied and worked in fields such as EMG, EEG, PSG, Dementia, Headache, and Vertigo. She has worked at Ağrı State Hospital Neurology Clinic, Hisar Intercontinental Hospital, and Medical Park Hospitals.
Lire la suiteHe was born in 1978 in Prizren (Kosovo). After graduating from "Prizren Science High School" in 1996, he started his education at Pristina University Faculty of Medicine in 1996 and graduated from Kocaeli University Faculty of Medicine between 1999-2005. Between 2006-2011, he completed his specialty training in Neurology at Marmara University Faculty of Medicine, Department of Neurology. During her training, she was especially interested in electrophysiology, dementias and movement disorders. Between 2012-2013, she worked as a lecturer at Üsküdar University. Since 2013, she has been working as a Neurology specialist at NPIstanbul Brain Hospital. She has ongoing scientific studies in the field of neurology. He speaks fluent English, Serbian and Bosnian. In his free time, he is engaged in classical Turkish music.
Publications:
Education and Expertise
1998 - 2005 - Marmara University Faculty of Medicine
1998 - 2005 - Marmara University, Faculty of Medicine, Department of Neurosurgery, Istanbul
(Head of the Department: Prof Dr Türker KILIÇ)
2011 - 2012 - Yale School of Medicine, New Haven, CT, USA (Director: Murat Günel MD. PhD., Professor of Neurosurgery)Cerebrovascular Research Fellowship
Professional Memberships
2014 + Turkish Neurosurgery Association
2017 + Turkish Spine Association
2018 + AOSpine
Awards
Turkish Neurosurgery Society 31st Scientific Congress “Prof. Dr. Hamit Ziya Gökalp Young Neurosurgeon Encouragement First Prize”, Antalya, 2017.
Courses and Certificates
1. Member of the Organizing Committee; 12. National Neuroscience Congress, Bahçeşehir University, 28-31 May 2014
2. Member of the Organizing Committee; 11. ASNO 'Skull-base Anatomy Course', 11-14 September 2014, Istanbul
3. Instructor / Member of the Organizing Committee; Neurosurgery Course Series – 4 /Prof. Dr. Evandro de Oliveira Skull Base Course 2, Prof. Rhoton Anatomy Lab BAU Faculty of Medicine, Istanbul, 2015.
4. Member of the Organizing Committee; International Deep Brain Stimulation Surgery Microelectrode Recording Cadaver Course, Rhoton Anatomy Lab BAU Faculty of Medicine, 6-7 February 2015 Istanbul.
5. Organization Officer; TND Istanbul Meetings, Istanbul, 2015-2016
Lire la suiteEducation and Specialization:
Professional Experience:
Areas of Expertise:
Research and Publications: Prof. Dr. Arslan has numerous publications in prestigious journals, covering topics such as the treatment of brain and spinal tumors, innovative neurosurgical techniques, and outcomes of neurosurgical interventions. His work includes studies on brain ischemia/reperfusion injury, spinal cord ischemia, and various other neurosurgical conditions.
Professional Memberships:
Neurosurgery Training: Gazi University, Department of Neurosurgery, 2011
H index: 10, I10 Index: 12 Citations: 296
Dr Mehmet Tonge has international and nationwide 32 publications, 12 book chapters, 92 oral and poster presentations and 41 invited lectures, mostly on Stereotactic and Functional Neurosurgery.
Work & Training experience:
2004-2011: Gazi University, Department of Neurosurgery (Residency)
2008: Zurich University Hospital, Department of Neurosurgery (Intraoperative MRI applications), Switzerland
2008: Zurich University Hospital, Department of Neurosurgery: Microneurosurgery, white matter dissection, interventional neuroradiology courses, Switzerland
2011 – 2012: Sinop Ataturk State Hospital, Neurosurgeon
2012 – 2013: Cankiri State Hospital, Neurosurgeon
2013 – 2014: Istanbul Medipol University, Department of Neurosurgery & Gamma Knife Center (Ass Prof)
2013 – now: Maastricht University Neurosurgery & Neuroscience Department (Visiting scientist, PhDc) The Netherlands
2014: Maastricht University, The Netherlands: Deep Brain Stimulation Fellowship 2014-2018: Istanbul Memorial Hospital Neurosurgery: Staff Neurosurgeon
2016-2018: Istanbul Florence Nightingale Hospital (Consultant, Gamma Knife Center)
2018-now: Istanbul Medipol University (Stereotactic & Functional Neurosurgery, Gamma Knife Center) Ass. Prof.)
Dr Mehmet Tonge has completed 4-year cycle EANS (European Association of Neurosurgical Societies) Training courses.
Clinical areas of interest:
• Stereotactic & Functional Neurosurgery
• Surgery for movement disorders
• Gamma Knife Radiosurgery
• Surgery for pain & spasticity
• Psychosurgery
Research areas of interest:
• Deep brain stimulation
• Stereotactic radiosurgery
Administrative duties:
• Turkish Neurosurgical Society, Sterotactic & Functional Neurosurgery Section: Board member 2015- 2017
• Turkish Neurosurgical Society, Sterotactic & Functional Neurosurgery Section: Board member (Secretary) 2017-2019
• Turkish Skull Base Society: Board member 2016-2018
• Turkish Skull Base Society: Supervisory board member 2018-2020
• Deep Brain Stimulation and Movement Disorders Surgery Society: Executive Board Member, (Accountant) 2023-still
Memberships:
• WSSFN (World Stereotactic & Functional Neurosurgery Society)
• ESSFN (European Stereotactic & Functional Neurosurgery Society)
• Deep Brain Stimulation and Movement Disorders Surgery Society
• Deep Brain Stimulation Society
• International Stereotactic Radiosurgery Society
• Leksell Gamma Knife Society
• EANS (European Association of Neurosurgical Societies)
• Turkish Neurosurgical Society
• Turkish Skull Base Society
Sample Publications:
1. Tonge M. Technological developments in electric based DBS. Deep Brain Stimulation 2024 4(36-41) DOI: https://doi.org/10.1016/j.jdbs.2023.12.001
2. Akgul E, Onan HB, Islek I, Tonge M, Durmus Y, Barburoglu M, Azizova A, Erol C, Hakyemez B, Sencer S, Aydin K, Arat A. Flow diverter stents in the treatment of recanalized intracranial aneurysms. Interv Neuroradiol. 2021 Aug;27(4):481-489. doi: 10.1177/1591019921990507. Epub 2021 Jan 28. PMID: 33509011; PMCID: PMC8580529.
3. Mulders AEP, Temel Y, Tonge M, Schaper FLWVJ, van Kranen-Mastenbroek V,Ackermans L, Kubben P, Janssen MLF, Duits A. The association between surgical characteristics and cognitive decline following deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Clin Neurol Neurosurg. 2021 Jan;200:106341. doi: 10.1016/j.clineuro.2020.106341. Epub 2020 Nov 3. PMID: 33160716.
4. Wetzelaer P, Vlis T, Tonge M, Ackermans L, Kubben P, Evers S, Kocabicak E, Temel Y. Management of Hardware Related Infections after DBS Surgery: A Cost Analysis. Turk Neurosurg. 2018;28(6):929- 933. doi: 10.5137/1019-5149.JTN.21511-17.1. PMID: 29465741.
5. Bedirli N, Emmez G, Ünal Y, Tönge M, Emmez H. Effects of positive end- expiratory pressure on intracranial pressure during pneumoperitoneum and Trendelenburg position in a porcine mode. Turk J Med Sci. 2017 Nov 13;47(5):1610-1615. doi: 10.3906/sag-1609-17. PMID: 29152942.
6. Sari R, Tonge M, Bolukbasi FH, Onoz M, Baskan O, Silav G, Elmaci I. Management of Failed Cranioplasty. Turk Neurosurg. 2017;27(2):201-207. doi: 10.5137/1019-5149.JTN.15395-15.0. PMID: 27593759.
7. Tonge M, Kocabicak E, Ackermans L, Kuijf M, Temel Y. Final Electrode Position in Subthalamic Nucleus Deep Brain Stimulation Surgery: A Comparison of Indirect and Direct Targeting Methods. Turk Neurosurg. 2016;26(6):900-903. doi: 10.5137/1019-5149.JTN.13739-14.1. PMID: 27337232.
8. Tonge M, Ackermans L, Kocabicak E, van Kranen-Mastenbroek V, Kuijf M, Oosterloo M, Kubben P, Temel Y. A detailed analysis of intracerebral hemorrhages in DBS surgeries. Clin Neurol Neurosurg. 2015 Dec;139:183-7. doi: 10.1016/j.clineuro.2015.10.017. Epub 2015 Oct 23. PMID: 26513430.
9. Silav G, Bölükbaşı FH, Özek E, Tönge M, Önöz M, Elmacı İ. A Simple Technique for Bone Storage after Decompressive Craniectomy in Children. Pediatr Neurosurg. 2015;50(3):161-4. doi: 10.1159/000381748. Epub 2015 May 14. PMID: 25998533.
10. Yilmaz MB, Donmez H, Tonge M, Senol S, Tekiner A. Vertebrojugular arteriovenous fistula and pseudoaneurysm formation due to penetrating vertebral artery injury: case report and review of the literature. Turk Neurosurg. 2015;25(1):141-5. doi: 10.5137/1019-5149.JTN.8247-13.1. PMID: 25640560.
11. Kurt G, Tönge M, Çeltıkçı E, Çapraz I, Serdaroğlu A, Bılır E. Surgery for intractable temporal lobe epilepsy: experience of a single institution. Turk J Med Sci. 2014;44(5):866-70. doi: 10.3906/sag-1307- 30. PMID: 25539559.
12. Yılmaz MB, Tönge M, Emmez H, Kaymaz F, Kaymaz M. Neuroprotective effects of quetiapine on neuronal apoptosis following experimental transient focal cerebral ischemia in rats. J Korean Neurosurg Soc. 2013 Jul;54(1):1-7. doi: 10.3340/jkns.2013.54.1.1. Epub 2013 Jul 31. PMID: 24044072; PMCID: PMC3772279.
13. Yilmaz MB, Egemen E, Tonge M, Kaymaz M. Transoral protrusion of a peritoneal catheter due to gastric perforation 10 years after a ventriculoperitoneal shunting: case report and review of the literature. Turk Neurosurg. 2013;23(2):285-8. doi: 10.5137/1019-5149.JTN.4904-11.1. PMID: 23546921.
14. Omerhodzic I, Tonge M, Matos B, Musabeliu E, Raspanti C, Ferdinandov D, Galimova R, Muroi C, Balik V, Kursumovic A. Neurosurgical training programme in selected European countries: from the young neurosurgeons' point of view. Turk Neurosurg. 2012;22(3):286-93. doi: 10.5137/1019- 5149.JTN.5133-11.0. PMID: 22664994.
15. Ergun E, Kurt G, Tonge M, Aytar H, Tas M, Baykaner K, Ceviker N. Effects of phenytoin sodium on dura mater healing in a rat model of CSF leakage. Turk Neurosurg. 2011;21(4):471-6. PMID: 22194102.
16. Emmez H, Tonge M, Tokgoz N, Durdag E, Gonul I, Cevıker N. Radiological and histopathological comparison of microporous polysaccharide hemospheres and oxidized regenerated cellulose in the rabbit brain: a study of efficacy and safety. Turk Neurosurg. 2010 Oct;20(4):485-91. doi: 10.5137/1019- 5149.JTN.3300-10.2. PMID: 20963698.
17. Emmez H, Yildirim Z, Kale A, Tönge M, Durdağ E, Börcek AO, Uçankuş LN, Doğulu F, Kiliç N, Baykaner MK. Anti-apoptotic and neuroprotective effects of α-lipoic acid on spinal cord ischemiareperfusion injury in rabbits. Acta Neurochir (Wien). 2010 Sep;152(9):1591-600; discussion 1600-1. doi: 10.1007/s00701-010-0703-9. Epub 2010 Jun 10. PMID: 20535507.
18. Kurt G, Tonge M, Börcek AO, Karahacioglu E, Gurel O, Baykaner K, Ceviker N, Aykol S. Fractionated gamma knife radiosurgery for optic nerve tumors: a technical report. Turk Neurosurg. 2010 Apr;20(2):241-6. doi: 10.5137/1019-5149.JTN.1681-09.3. PMID: 20401852.
19. Emmez H, Kale A, Tönge M, Cakir A, Ceviker N. Two meningiomas with different histological grades in the same patient. Case report. Neurol Med Chir (Tokyo). 2010;50(8):686-8. doi: 10.2176/nmc.50.686. PMID: 20805656.
Lire la suite2002-2007 Istanbul University Istanbul Faculty of Medicine Department of Brain and Nerve Surgery
1988-1995 Trakya University Faculty of Medicine
2015- Atlas University Medicine Hospital
2014-2015 Private Pendik Yüzyıl Hospital Brain and Neurosurgery Clinic
2009-2014 Medicine Hospital Brain and Neurosurgery Clinic
2009-2009 Nisa Hospital Brain and Neurosurgery Clinic
2007-2009 Mardin State Hospital Brain and Neurosurgery Clinic
2002-2007 Istanbul University Istanbul Faculty of Medicine Brain and Neurosurgery
1997-2001 Enez Health Center and Enez State Hospital
Cervical, Thoracic and Lumbar Disc Surgery (endoscopic/microsurgery)
Far lateral (non-canal) lumbar disc surgery (lateral microsurgical approach)
Neurovascular surgery
Cerebrovascular diseases (vascular diseases of the brain)
Aneurysms
Arteriovenous malformations
Cavernomas
Neuro-oncological surgery
Brain tumors
Glial tumors
Meningiomas
Pituitary gland tumors
Metastatic brain tumors
Skull base tumors
Pontocerebellar angle tumors
Pineal tumors
Intraventricular tumors
Spinal disease surgery
Cervical, thoracic and lumbar spine fractures
Spine and spinal cord tumors
Scoliosis
Degenerative spine diseases
Peripheral nerve disease surgery
Peripheral nerve tumors
Entrapment neuropathies
Carpal tunnel syndrome
Ulnar groove syndrome
Tarsal tunnel syndrome
Functional neurosurgery and pain surgery
Trigeminal neuralgia
Microvascular decompression
Epilepsy surgery
Spasticity surgery
Epiduroscopic interventions
Hydrocephalus surgeries
Endoscopic 3rd ventriculostomy
VP shunt surgeries
LP shunt surgeries
Developmental anomalies
Meningomyelocele
Tethered cord syndrome
Arachnoid cyst
Craniosynostosis surgeries
Chiari malformation
Head trauma
Subdural hematomas
Intracerebral hematomas
Article published in internationally refereed journals
Cansever T, Civelek E, Sencer A, Karasu A, Kiris T, Hepgül K, Can H, Canbolat A: Spinal cavernous malformations: a report of 5 cases. Surg Neurol Jun 69
Effects of combined and individual use of N-methyl-D aspartate receptor antagonist magnesium sulphate and caspase-9 inhibitor z-LEDH-fmk experimental spinal cord injury. A.Sencer, A.Aydoseli, Y.Aras, M.Osman Akçakaya, C.Gömleksiz, H.Can, A.Canbolat. Turkısh Joumal of Trauma&Emergency Surgery 2013
Aydoseli A, Can H, Aras Y, Sabanci PA, Akcakaya MO, Unal OF. Memantine and Q-VD-OPh Treatments in Experimental Spinal Cord Injury: Combined Inhibition of Necrosis and Apoptosis. Turk Neurosurg. 2016
Can H, Kircelli A, Kavadar G, Civelek E, Cansever T, Aydoseli A, Onal MB, Yilmaz C. Lumbosacral Conjoined Root Anomaly: Anatomical Considerations of Exiting Angles and Root Thickness. Turk Neurosurg. 2017
Kırcelli A, Özel Ö, Can H, Sarı R, Cansever T, Elmacı İ. Is the presence of linear fracture a predictor of delayed posterior fossa epidural hematoma? Ulus Travma Acil Cerrahi Derg. 2016 Jul
Kavadar G, Demircioğlu DT, Can H, Emre TY, Civelek E, Senyigit A. The clinical factors associated with benefit finding of complementary medicine use in patients with back pain: A cross-sectional study with cluster analysis. J Back Musculoskelet Rehabil. 2017
Ozer AF, Suzer T, Can H, Falsafi M, Aydin M, Sasani M, Oktenoglu T. Anatomic Assessment of Variations in Kambin’s Triangle: A Surgical and Cadaver Study. World Neurosurg. 2017 Apr
Can H, Aydoseli A, Gömleksiz C, Göker B, Altunrende ME, Dolgun M, Sencer A. Combined and individual use of pancaspase inhibitor Q-VD-OPh and NMDA receptor antagonist riluzole in experimental spinal cord injury. Ulus Travma Acil Cerrahi Derg. 2017
Gomleksiz C, Erbulut DU, Can H, Kodigudla MK, Kelkar AV, Kasapoglu E, Ozer AF, Goel VK. A new lumbar fixation device alternative to pedicle-based stabilization for lumbar spine: In vitro cadaver investigation. J Spinal Cord Med. 2018 Jul 16:1-8.
Aydoseli A, Özgen U, Akgül T, Orhan EK, Adıyaman AE, Can H, Karadağ C. Subacute Traumatic Ascending Myelopathy in a 28-year-old man: A rare case. World Neurosurg. 2019 Apr 28
Article published in national refereed journals
1) Intracranial Hemangioblastomas: Clinical Evaluation of 32 Patients T. Cansever, A. Karasu, K. Hepgül, H. Can, A. Sencer Turkish Neurosurgical Journal 2007, Volume:17
2) Halil Can, Müge Dolgun, Utku Özgen, Cengiz Gömleksiz, Furkan Diren, Aydın Aydoseli, Yavuz Aras, Altay Sencer. Microsurgical Results in Vestibular Schwannoma Patients; Retrospective Clinical Study. JAREM 2019
3) Furkan Diren , Özcan Gayretli , Halil Can , İlke Ali Gürses , Orhan Barlas. Examination of Pons-Cerebellum Cisterna Anatomy with Endoscopic Retrosigmoid Suboccipital Approach: Cadaver Study. JAREM 2019
Lire la suiteAssoc. Prof. Ali Zirh is a world renowned neurosurgeon from Turkey. He was born on October 8, 1960 in Ankara, Türkiye and completed his primary and secondary education in the same city. He graduated from Ankara Atatürk High School with first place, and he entered the Hacettepe University Faculty of Medicine. He graduated from Hacettepe University Faculty of Medicine on August 31st, 1983 as a medical doctor. Between the years 1983 and 1985, he carried out his state service obligation in Gaziantep and was rewarded with a commendation by the Provincial Authority for his work in this period. He completed his military service in Istanbul in 1987 and was discharged.
In 1988, he started his specialization at Marmara University Faculty of Medicine, Department of Neurosurgery. In 1990, he attended the British Council in Glasgow and Edinburgh; the European Neurosurgery Association (EANS) in Warnemünde, Germany in 1989; Zaragoza, Spain in 1991; Jerusalem, Israel in 1992; Brudge, Belgium in 1993; and in 1994, he attended the World Neurosurgery Association (WFNS) training courses in Antalya, Turkey.
Glasgow Institute of Neurological Sciences in 1990, Department of Neurosurgery, University of Pittsburg in 1992, Department of Neurosurgery, University of Virginia in 1992, Department of Neurosurgery, University of Washington in 1992, Division of Neurosurgery, Toronto Western Hospital in 1994, Department of Neurosurgery, The Johns Hopkins Hospital in 1994 he visited and participated in clinical studies.
He became a neurosurgeon in February 1994. He completed his master's degree in neurophysiology at Marmara University Health Sciences Institute in March 1994. In September 1994, he completed the fifth of the European Neurosurgery Association's (EANS) training courses in Izmir, took the exams, and received his EANS diploma. On the same date, he participated in the European Board of Neurosurgery Primary Examination, passed successfully and certified.
In line with his field of interest, Stereotactic and Functional Neurosurgery, he attended training courses on "Stereotactic Target Calculation" and "Neurostimulation for Pain" in Çeşme İzmir in September 1994. "Stereotactic Neurosurgery Hands-On" in New-Orleans USA in November 1994, "Augmentitative Procedures for Pain" in San Francisco USA in October 1995, "Stereotactic Neurosurgery Hands" in New Orleans-USA in November 1995 , "Deep Brain Stimulation for Treating Parkinson's Disease" in Minneapolis-USA in May 1996, "Interventional Therapies Workshop: Implantable Spinal Cord Stimulation and Drug Infusion Systems" in Washington-USA in May 1996, "Surgical Treatment for Movement Disorders" and" Interventional Therapies in Chronic Pain Management" in Montreal-Canada in October 1996, "Management of Patients with Deep-Brain Stimulators, Expert Course and Workshop" in Kiel-Germany in June 2001.
Dr. Ali ZIRH returned from the United States in 1997 and started to work at the VKV American Hospital, performing functional neurosurgery interventions and DBS insertion with the Microelectrode Recording and Stimulation technique at the single cell level, which is available in only a few centers in the world.
He started to work at Medicalpark Bahçelievler Hospital as of January 2009 and implemented these initiatives in a health institution where Social Security Institution patients could also benefit. He continues his surgical interventions at Medipol Bağcılar Hospital as of January 2015.
As of September 2018, he continues his academic and clinical studies at Medipol University's Parkinson's Disease and Movement Disorder Center (PARMER).
Over 30 years of clinical and surgical experience in the field of functional neurosurgery, more than 1900 surgical interventions for Parkinson’s and other movement disorder diseases and more than 1400 DBS surgeries that he has successfully performed, made Dr. Ali ZIRH the first name that comes to mind in movement disorder surgery in Turkey and the adjacent geography. He enabled the center where he performs these surgeries to become a Training and Reference Center in the international arena.
Dr. Ali ZIRH is a member of the Turkish Neurosurgery Association, Parkinson's Disease Association, European Society of Stereotactic and Functional Neurosurgery, American Academy of Advancement of Science, World Federation of Stereotactic and Functional Neurosurgery, International Association for the Study of Pain, American Pain Society, World Neuromodulation, American Neuromodulation Society, American Society of Stereotactic and Functional Neurosurgery, The Movement Disorder Society, American Association of Neurological Surgeons (AANS), and the Congress of Neurological Surgeons (CNS). At the international congresses and symposiums of these organizations held in different parts of the world at least 4-5 times a year, Dr. Zirh shares his experiences with other colleagues at these meetings, and also follows the progress and developments in his field of expertise day by day.
Dr. Ali ZIRH has many publications published in international journals, eight book chapters, more than 150 congress papers and various national / international awards.
Lire la suite
Medical Area of Interest and Activities
Functional Neurosurgery (Parkinson’s, Deep Brain Stimulation)
Brain and Spinal tumors
Spinal degenerative diseases Education
Istanbul University Cerrahpaşa Faculty of Medicine
Trakya University Faculty of Medicine Brain and Nerve Surgery
Experience
Ankara Gülhane Military Medical Academy Brain and Nerve Surgery
Osmaniye State Hospital
Bolu State Hospital
Private Taksim German Hospital
Taksim Training and Research Hospital
Istanbul University Faculty of Medicine Brain and Nerve Surgery
Liv Hospital Ulus
Memberships
Turkish Neurosurgery Society
Turkish Medical Association
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