Sheba Pediatric CAR-T Program for Primary CNS Lymphoma
Qu'est-ce qui est inclus dans ce forfait
Procédures Médicales
- Consultation avec un hématologue
- Diagnostic complet des lymphomes
- Analyse approfondie du sang
- Prise de sang pour lymphome
- TEP/TDM dans le lymphome
- Biopsie du ganglion lymphatique sentinelle
- Diagnostic oncologique complexe
- Сonsultation avec un oncohématologue
- Thérapie CAR T
- Test anti-VIH
- Test anti-HBC
- Test anti-VHCAb
- Des analyses de sang
- Test sanguin de biochimie
- Biopsie
- Radiographie pulmonaire
- Formule sanguine complète (CBC)
- Consultation avec un oncologue
- Consultation avec un hématologue
- Consultation avec un immunologiste
- Consultation avec un hématologue pédiatrique
- Consultation avec un pédiatre
- Formule sanguine complète avec marqueurs de cancer et protéinogramme
- Électrocardiogramme
- Échocardiographie
- Consultation avec un cardiologue
- IRM de la tête
- TEP/TDM
- Сonsultation avec un oncohématologue
- Service infirmier 24h/24
- 3 repas par jour élaborés par un nutritionniste
Durée
- 21 jours à l'hôpital
Hébergement
Hospitalisation
Transport
Transfert aéroport-clinique-aéroport
Informations complémentaires
Sheba Pediatric CAR-T Program for Primary CNS Lymphoma
At Sheba Medical Center, children and young patients with primary central nervous system (CNS) lymphoma have access to one of the most advanced and specialized CAR-T therapy programs in the world. This rare and complex lymphoma, affecting the brain and spinal cord, requires highly precise and coordinated care, especially in relapsed or treatment-resistant cases.
A Personalized Treatment Designed for Each Patient
CAR-T therapy uses the patient’s own immune system to recognize and destroy cancer cells. For CNS lymphoma, this innovative approach offers a targeted option when conventional therapies are no longer sufficient.
At Sheba, the entire CAR-T process is performed on-site, ensuring speed, precision, and optimal cell quality:
Apheresis – collection of the patient’s T-cells
Cell Engineering – genetic modification at Sheba’s Advanced Biotherapy Center
Infusion – reintroduction of modified cells to target lymphoma cells
Because no steps are outsourced, treatment can begin quickly and is typically completed within ~10 days. CAR-T acts as a “living therapy,” continuing to work in the body and offering the potential for long-term disease control.
Expert Pediatric Leadership and Multidisciplinary Care
The program is led by Prof. Amos Toren, a globally recognized expert in pediatric hemato-oncology and cellular therapies, with decades of experience and over 1,500 bone marrow transplants performed.
Given the complexity of CNS lymphoma, care is delivered through a multidisciplinary team, including pediatric hemato-oncologists, neurologists, neurosurgeons, and radiology experts.
The program includes:
Specialized pediatric CAR-T units with 24/7 monitoring
Advanced neuro-imaging and precision diagnostics
A supportive, family-centered environment
Full international patient services, including travel and care coordination
Proven Expertise in Complex and High-Risk Cases
Sheba is a global leader in CAR-T therapy, with strong outcomes across hematologic cancers:
~90% remission in pediatric patients
~80% in young adults (up to 23 years)
~70% in adults
The team has extensive experience in treating rare and high-risk conditions, including CNS involvement, offering advanced options when other treatments are limited.
Comprehensive Evaluation and Ongoing Support
Each patient undergoes a full diagnostic work-up, including:
advanced brain and spinal imaging (MRI/CT), bone marrow evaluation, genetic and molecular testing, and cardiac and pulmonary assessment.
Care is provided in English, Russian, and Arabic, ensuring families feel supported and informed throughout the entire journey.
A Trusted Place for Advanced Pediatric Neuro-Oncology Care
By combining cutting-edge immunotherapy, neurological expertise, and compassionate care, Sheba provides one of the most advanced environments for treating primary CNS lymphoma with CAR-T—focused on achieving the best possible outcomes and quality of life for every patient.
Assistance Bookimed 24/7
- Coordinateur médical personnel
- Organisation de voyage médical — réservation des tickets de vol et des chambres d'hôtel à des prix réduits pour les partenaires
- Prise en charge du patient lors d'un voyage médical
Prix du programme
Ce qui n'est PAS inclus dans ce forfait
Médecin
Prof. Amos Toren, MD, PhD, MHA, is a pediatric hemato-oncologist and BMT specialist. He served as Director of Pediatric Hemato-Oncology and BMT at Sheba Medical Center.
He is board certified in Pediatrics, Pediatric Hemato-Oncology, and Bone Marrow Transplantation. He holds a PhD in Human Genetics. He was Head of the Hematology Division at Tel Aviv University for two terms. He is a member of ASH, COG, ESPHI, EBMT, and CIBMTR. He also serves on the Ministry of Health Cord Blood Committee.
He led one of Israel’s most advanced pediatric oncology and BMT programs. The program treated children and young adults. His focus includes leukemia and lymphoma, immunodeficiencies, and rare cancers. He specializes in BMT and CAR T-cell therapy.
His translational research covers CAR T cells, cytokine-induced killer cells, pediatric brain tumors, and targeted therapies. He has worked with St. Anna, the NIH, and St. Jude. His publications include studies on pediatric SCT prophylaxis and PARP resistance.
Où en sommes-nous ?
À propos de la clinique
Le centre médical Sheba est l'un des meilleurs hôpitaux d'Israël et du monde. Le magazine Newsweek International a classé l' hôpital Sheba parmi les 10 meilleurs hôpitaux du monde en 2020. L'hôpital couvre 1 990 spécialités et plus de 1 500 000 patients du monde entier se rendent à l'hôpital Sheba pour se faire soigner chaque année.
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