{"key":"op_409_IL","page":{"url":"https://fr.bookimed.com/clinics/country=israel/procedure=complex-treatment-of-neuroblastoma/","procedure":{"id":409,"slug":"complex-treatment-of-neuroblastoma","name":"Traitement complexe du neuroblastome","name_forms":{"plural":{"status":"missing","reason":"not_collected"},"genitive":{"status":"missing","reason":"not_collected"}},"type":"therapy","grammar_number":{"status":"missing","reason":"not_collected"},"parent_id":"pediatric-oncology","family_attribute":{"status":"missing","reason":"not_collected"}},"country":{"id":1,"iso":"IL","name":"Israël"},"currency":"USD","data_date":{"status":"missing","reason":"not_collected"}},"pages":{"clinics_url":"https://fr.bookimed.com/clinics/country=israel/procedure=complex-treatment-of-neuroblastoma/","cost_url":"https://fr.bookimed.com/clinics/country=israel/procedure=complex-treatment-of-neuroblastoma/cost/","best_url":{"status":"missing","reason":"template not live"}},"price":{"from":74500,"to":170000,"avg":{"value":74500,"method":"median","source":"offers"},"us":{"from":160000,"to":350000},"uk":{"from":185000,"to":340000},"by_technique":{"status":"missing","reason":"not_collected"},"by_city":[{"city":"Ramat Gan","from":74500},{"city":"Tel Aviv","from":95000}],"per_unit":{"status":"missing","reason":"not_collected"},"factors":{"status":"missing","reason":"not_collected"},"tiers":{"source":"offers","items":[{"tier":"premium","min":74500,"max":74500,"median":74500,"count":1}]},"comparison":[{"country_iso":"UA","from":12000,"to":30000},{"country_iso":"FR","from":85000,"to":135000},{"country_iso":"GB","from":185000,"to":340000},{"country_iso":"US","from":160000,"to":350000},{"country_iso":"TR","from":38000,"to":60000},{"country_iso":"MX","from":38000,"to":68000},{"country_iso":"DE","from":85000,"to":160000},{"country_iso":"CA","from":180000,"to":320000},{"country_iso":"AE","from":45000,"to":85000},{"country_iso":"TH","from":30000,"to":45000},{"country_iso":"PL","from":28000,"to":55000},{"country_iso":"KR","from":85000,"to":135000},{"country_iso":"CZ","from":45000,"to":85000},{"country_iso":"AT","from":85000,"to":165000},{"country_iso":"ES","from":65000,"to":125000},{"country_iso":"IT","from":95000,"to":165000},{"country_iso":"CN","from":40000,"to":85000},{"country_iso":"AU","from":120000,"to":210000},{"country_iso":"IN","from":16000,"to":30000},{"country_iso":"MY","from":28000,"to":50000},{"country_iso":"VN","from":24500,"to":52000},{"country_iso":"BR","from":45000,"to":70000}],"base_country":"US","base_is_fallback":false},"savings":{"pct":53,"variant":"ranges_overlap"},"package":{"included":["24-hr nurse services","3 meals per day by nutritionist","Anti-HBC test","Anti-HCVAb test","Anti-HIV test","Biochemistry blood test","Biopsy","Blood tests","Chest X-ray","Complete blood count (CBC)","Complete blood count with cancer markers and a proteinogram","Computerized Bone Mineralometry (CBM)","Consultation with a cardiologist","Consultation with a pediatric hematologist","Consultation with a pediatrician","Consultation with an immunologist","Consultation with an oncologist","Echocardiography","Electrocardiogram (ECG)","Head MRI","Hospitalization","PET/CT","Transfer airport-clinic-airport","Сonsultation with an oncohematologist"],"excluded":{"status":"missing","reason":"not_collected"},"extra_charges":{"status":"missing","reason":"not_collected"}},"clinics":{"count":1,"items":[{"id":9,"name":"Sheba Medical Center","city":"Ramat Gan","rating":5,"reviews_count":2,"accreditations":["Best Maternity Hospitals 2021 by Newsweek","World's Best Smart Hospitals 2021 by Newsweek","World's Best Hospitals 2021 by Newsweek","World's Best Hospitals 2020 by Newsweek","Joint Commission International","International Organization for Standardization","World's Best Specialized Hospitals 2022 by Newsweek","World's Best Smart Hospitals 2023 by Newsweek","World's Best Hospitals 2022 by Newsweek","World's Best Hospitals 2026 by Newsweek","World's Best Hospitals 2025 by Newsweek"],"rank":1,"has_procedure":true,"why_ranked":"Dedicated pediatric hemato-oncology division sees 4,000 outpatients annually. Offers autologous, allogeneic, and haploidentical transplants in HEPA-filtered rooms with a specialized HLA lab, led by a neuroblastoma specialist.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":[{"id":"69f13bf0b64b0268790ac872","price":74500,"nights":30,"included":["3 meals per day by nutritionist","24-hr nurse services","Electrocardiogram (ECG)","Blood tests","Chest X-ray","Anti-HIV test","Anti-HBC test","Anti-HCVAb test","Echocardiography","Complete blood count (CBC)","Biochemistry blood test","PET/CT","Consultation with an oncologist","Consultation with an immunologist","Consultation with a cardiologist","Consultation with a pediatric hematologist","Consultation with a pediatrician","Сonsultation with an oncohematologist","Head MRI","Biopsy","Computerized Bone Mineralometry (CBM)","Complete blood count with cancer markers and a proteinogram","Hospitalization","Transfer airport-clinic-airport"],"excluded":{"status":"missing","reason":"not_collected"},"other_services":"Autologous Stem Cell Transplantation (Autologous Bone Marrow Transplantation) for Pediatric Neuroblastoma Sheba Medical Center – Advanced, Personalized Transplant Care for Children At Sheba Medical Center, we understand how challenging it is for families to face a diagnosis of neuroblastoma. This complex childhood cancer requires not only advanced medical expertise, but also compassionate, family-centered care. For children with high-risk or relapsed neuroblastoma, bone marrow transplantation (BMT) plays a vital role in treatment offering a powerful approach aimed at improving long-term outcomes and giving children the best possible chance for recovery. Our pediatric transplant program combines world-leading expertise, innovative therapies, and a supportive environment designed specifically for children and their families. When is a Bone Marrow Transplant Needed? In neuroblastoma, bone marrow transplantation is typically part of an intensive treatment strategy and may be recommended when: The disease is high-risk at diagnosis Neuroblastoma has spread beyond the original tumor site The disease returns after initial treatment BMT allows doctors to use high-dose therapy to eliminate cancer cells, followed by the infusion of healthy stem cells to restore the bone marrow and immune system. Types of Transplant Autologous Transplant (Child’s Own Cells) For most children with neuroblastoma, this is the standard approach. Stem cells are collected from the child in advance High-dose therapy is delivered to target remaining cancer cells The child’s own cells are reinfused to rebuild healthy bone marrow In selected cases, tandem (double) transplants may be recommended to further strengthen treatment outcomes. Allogeneic Transplant (Donor Cells) While autologous transplantation is the most common approach, Sheba Medical Center also offers advanced allogeneic (donor) transplantation for carefully selected cases. This option may be considered for: Children who need an alternative stem cell source Children who require an additional therapeutic strategy after prior treatment Donor Options at Sheba include: Matched sibling donors, when available Matched unrelated donors through international registries Haploidentical (half-matched) family donors, often a parent Sheba’s expertise allows access to the most suitable donor for every child, ensuring that no patient is left without options. A unique advantage of donor transplantation is the graft-versus-tumor effect, where the new immune system can help recognize and fight any remaining neuroblastoma cells. Precision Matching and Advanced Technology Successful transplantation begins with the best possible donor match. Sheba Medical Center operates an advanced on-site HLA laboratory, performing high-resolution genetic testing to ensure optimal compatibility between donor and child, enhancing safety and treatment effectiveness. Advanced Pediatric Neuroblastoma Care Sheba offers highly specialized treatment tailored to each child: Personalized transplant protocols Integration with immunotherapy and targeted treatments Advanced supportive care to promote recovery Close collaboration between pediatric oncology and transplant teams Specialized Pediatric Transplant Environment Children are treated in dedicated pediatric transplant units designed for safety, comfort, and healing: Child-friendly, highly protected environments Advanced infection prevention systems Continuous care by experienced pediatric specialists Every aspect of care is adapted to support children physically and emotionally. Clinical Expertise Sheba Medical Center is a leading center for pediatric cancer care, offering: Extensive experience in high-risk neuroblastoma Expertise in autologous and donor transplantation approaches Strong outcomes aligned with leading international centers Long-term follow-up focused on growth, development, and quality of life Care That Supports the Whole Family We understand that this journey involves the entire family. At Sheba, children and their families are supported by a multidisciplinary team including physicians, nurses, psychologists, and care coordinators ensuring guidance, reassurance, and continuous support at every stage. Why Families Choose Sheba for Pediatric BMT Leading pediatric transplant center Expertise in complex neuroblastoma cases Access to a wide range of donor options Advanced technologies and treatment approaches Child-focused, compassionate care Dedicated international patient services A Message of Hope At Sheba Medical Center, we combine innovation, expertise, and compassionate pediatric care to give every child the strongest possible chance for recovery, while supporting families with confidence, clarity, and hope every step of the way."}]}]},"doctors":{"count":2,"languages":{"status":"missing","reason":"not_collected"}},"cities":[{"id":5,"slug":"ramat-gan","name":"Ramat Gan","clinics_count":1,"price_from":74500,"profile":{"city_type":"City east of Tel Aviv, Israel","access":["Ben Gurion Airport (TLV), 20 km from Tel Aviv"],"sources":["https://en.wikipedia.org/wiki/Ramat_Gan","https://en.wikipedia.org/wiki/Ben_Gurion_Airport"],"checked_at":"2026-11-03","status":"ok"}},{"id":2,"slug":"tel-aviv","name":"Tel Aviv","clinics_count":{"status":"missing","reason":"not_collected"},"price_from":95000,"profile":{"city_type":"Mediterranean coastal economic and tech hub","access":["Ben Gurion Airport (TLV), 20 km southeast of city"],"sources":["https://en.wikipedia.org/wiki/Tel_Aviv","https://en.wikipedia.org/wiki/Ben_Gurion_Airport"],"checked_at":"2026-11-03","status":"ok"}}],"offers":{"active":1,"active_with_related":1,"hospital_nights_median":30,"days_in_country_median":{"status":"missing","reason":"fewer than 10 offers with hotel days"},"top_offers":[{"id":"69f13bf0b64b0268790ac872","clinic_id":9,"clinic_listed":true,"price":74500,"nights":30,"transfer":{"status":"missing","reason":"not_collected"},"tests":{"status":"missing","reason":"not_collected"},"meds":{"status":"missing","reason":"not_collected"},"aftercare":{"status":"missing","reason":"not_collected"},"guarantee":{"status":"missing","reason":"not_collected"},"included":["3 meals per day by nutritionist","24-hr nurse services","Electrocardiogram (ECG)","Blood tests","Chest X-ray","Anti-HIV test","Anti-HBC test","Anti-HCVAb test","Echocardiography","Complete blood count (CBC)","Biochemistry blood test","PET/CT","Consultation with an oncologist","Consultation with an immunologist","Consultation with a cardiologist","Consultation with a pediatric hematologist","Consultation with a pediatrician","Сonsultation with an oncohematologist","Head MRI","Biopsy","Computerized Bone Mineralometry (CBM)","Complete blood count with cancer markers and a proteinogram","Hospitalization","Transfer airport-clinic-airport"],"excluded":{"status":"missing","reason":"not_collected"},"other_services":"Autologous Stem Cell Transplantation (Autologous Bone Marrow Transplantation) for Pediatric Neuroblastoma Sheba Medical Center – Advanced, Personalized Transplant Care for Children At Sheba Medical Center, we understand how challenging it is for families to face a diagnosis of neuroblastoma. This complex childhood cancer requires not only advanced medical expertise, but also compassionate, family-centered care. For children with high-risk or relapsed neuroblastoma, bone marrow transplantation (BMT) plays a vital role in treatment offering a powerful approach aimed at improving long-term outcomes and giving children the best possible chance for recovery. Our pediatric transplant program combines world-leading expertise, innovative therapies, and a supportive environment designed specifically for children and their families. When is a Bone Marrow Transplant Needed? In neuroblastoma, bone marrow transplantation is typically part of an intensive treatment strategy and may be recommended when: The disease is high-risk at diagnosis Neuroblastoma has spread beyond the original tumor site The disease returns after initial treatment BMT allows doctors to use high-dose therapy to eliminate cancer cells, followed by the infusion of healthy stem cells to restore the bone marrow and immune system. Types of Transplant Autologous Transplant (Child’s Own Cells) For most children with neuroblastoma, this is the standard approach. Stem cells are collected from the child in advance High-dose therapy is delivered to target remaining cancer cells The child’s own cells are reinfused to rebuild healthy bone marrow In selected cases, tandem (double) transplants may be recommended to further strengthen treatment outcomes. Allogeneic Transplant (Donor Cells) While autologous transplantation is the most common approach, Sheba Medical Center also offers advanced allogeneic (donor) transplantation for carefully selected cases. This option may be considered for: Children who need an alternative stem cell source Children who require an additional therapeutic strategy after prior treatment Donor Options at Sheba include: Matched sibling donors, when available Matched unrelated donors through international registries Haploidentical (half-matched) family donors, often a parent Sheba’s expertise allows access to the most suitable donor for every child, ensuring that no patient is left without options. A unique advantage of donor transplantation is the graft-versus-tumor effect, where the new immune system can help recognize and fight any remaining neuroblastoma cells. Precision Matching and Advanced Technology Successful transplantation begins with the best possible donor match. Sheba Medical Center operates an advanced on-site HLA laboratory, performing high-resolution genetic testing to ensure optimal compatibility between donor and child, enhancing safety and treatment effectiveness. Advanced Pediatric Neuroblastoma Care Sheba offers highly specialized treatment tailored to each child: Personalized transplant protocols Integration with immunotherapy and targeted treatments Advanced supportive care to promote recovery Close collaboration between pediatric oncology and transplant teams Specialized Pediatric Transplant Environment Children are treated in dedicated pediatric transplant units designed for safety, comfort, and healing: Child-friendly, highly protected environments Advanced infection prevention systems Continuous care by experienced pediatric specialists Every aspect of care is adapted to support children physically and emotionally. Clinical Expertise Sheba Medical Center is a leading center for pediatric cancer care, offering: Extensive experience in high-risk neuroblastoma Expertise in autologous and donor transplantation approaches Strong outcomes aligned with leading international centers Long-term follow-up focused on growth, development, and quality of life Care That Supports the Whole Family We understand that this journey involves the entire family. At Sheba, children and their families are supported by a multidisciplinary team including physicians, nurses, psychologists, and care coordinators ensuring guidance, reassurance, and continuous support at every stage. Why Families Choose Sheba for Pediatric BMT Leading pediatric transplant center Expertise in complex neuroblastoma cases Access to a wide range of donor options Advanced technologies and treatment approaches Child-focused, compassionate care Dedicated international patient services A Message of Hope At Sheba Medical Center, we combine innovation, expertise, and compassionate pediatric care to give every child the strongest possible chance for recovery, while supporting families with confidence, clarity, and hope every step of the way.","is_package":true}],"packages":[{"id":"69f13bf0b64b0268790ac872","clinic_id":9,"clinic_listed":true,"price":74500,"nights":30,"transfer":{"status":"missing","reason":"not_collected"},"tests":{"status":"missing","reason":"not_collected"},"meds":{"status":"missing","reason":"not_collected"},"aftercare":{"status":"missing","reason":"not_collected"},"guarantee":{"status":"missing","reason":"not_collected"},"included":["3 meals per day by nutritionist","24-hr nurse services","Electrocardiogram (ECG)","Blood tests","Chest X-ray","Anti-HIV test","Anti-HBC test","Anti-HCVAb test","Echocardiography","Complete blood count (CBC)","Biochemistry blood test","PET/CT","Consultation with an oncologist","Consultation with an immunologist","Consultation with a cardiologist","Consultation with a pediatric hematologist","Consultation with a pediatrician","Сonsultation with an oncohematologist","Head MRI","Biopsy","Computerized Bone Mineralometry (CBM)","Complete blood count with cancer markers and a proteinogram","Hospitalization","Transfer airport-clinic-airport"],"excluded":{"status":"missing","reason":"not_collected"},"other_services":"Autologous Stem Cell Transplantation (Autologous Bone Marrow Transplantation) for Pediatric Neuroblastoma Sheba Medical Center – Advanced, Personalized Transplant Care for Children At Sheba Medical Center, we understand how challenging it is for families to face a diagnosis of neuroblastoma. This complex childhood cancer requires not only advanced medical expertise, but also compassionate, family-centered care. For children with high-risk or relapsed neuroblastoma, bone marrow transplantation (BMT) plays a vital role in treatment offering a powerful approach aimed at improving long-term outcomes and giving children the best possible chance for recovery. Our pediatric transplant program combines world-leading expertise, innovative therapies, and a supportive environment designed specifically for children and their families. When is a Bone Marrow Transplant Needed? In neuroblastoma, bone marrow transplantation is typically part of an intensive treatment strategy and may be recommended when: The disease is high-risk at diagnosis Neuroblastoma has spread beyond the original tumor site The disease returns after initial treatment BMT allows doctors to use high-dose therapy to eliminate cancer cells, followed by the infusion of healthy stem cells to restore the bone marrow and immune system. Types of Transplant Autologous Transplant (Child’s Own Cells) For most children with neuroblastoma, this is the standard approach. Stem cells are collected from the child in advance High-dose therapy is delivered to target remaining cancer cells The child’s own cells are reinfused to rebuild healthy bone marrow In selected cases, tandem (double) transplants may be recommended to further strengthen treatment outcomes. Allogeneic Transplant (Donor Cells) While autologous transplantation is the most common approach, Sheba Medical Center also offers advanced allogeneic (donor) transplantation for carefully selected cases. This option may be considered for: Children who need an alternative stem cell source Children who require an additional therapeutic strategy after prior treatment Donor Options at Sheba include: Matched sibling donors, when available Matched unrelated donors through international registries Haploidentical (half-matched) family donors, often a parent Sheba’s expertise allows access to the most suitable donor for every child, ensuring that no patient is left without options. A unique advantage of donor transplantation is the graft-versus-tumor effect, where the new immune system can help recognize and fight any remaining neuroblastoma cells. Precision Matching and Advanced Technology Successful transplantation begins with the best possible donor match. Sheba Medical Center operates an advanced on-site HLA laboratory, performing high-resolution genetic testing to ensure optimal compatibility between donor and child, enhancing safety and treatment effectiveness. Advanced Pediatric Neuroblastoma Care Sheba offers highly specialized treatment tailored to each child: Personalized transplant protocols Integration with immunotherapy and targeted treatments Advanced supportive care to promote recovery Close collaboration between pediatric oncology and transplant teams Specialized Pediatric Transplant Environment Children are treated in dedicated pediatric transplant units designed for safety, comfort, and healing: Child-friendly, highly protected environments Advanced infection prevention systems Continuous care by experienced pediatric specialists Every aspect of care is adapted to support children physically and emotionally. Clinical Expertise Sheba Medical Center is a leading center for pediatric cancer care, offering: Extensive experience in high-risk neuroblastoma Expertise in autologous and donor transplantation approaches Strong outcomes aligned with leading international centers Long-term follow-up focused on growth, development, and quality of life Care That Supports the Whole Family We understand that this journey involves the entire family. At Sheba, children and their families are supported by a multidisciplinary team including physicians, nurses, psychologists, and care coordinators ensuring guidance, reassurance, and continuous support at every stage. Why Families Choose Sheba for Pediatric BMT Leading pediatric transplant center Expertise in complex neuroblastoma cases Access to a wide range of donor options Advanced technologies and treatment approaches Child-focused, compassionate care Dedicated international patient services A Message of Hope At Sheba Medical Center, we combine innovation, expertise, and compassionate pediatric care to give every child the strongest possible chance for recovery, while supporting families with confidence, clarity, and hope every step of the way.","is_package":true}],"related_packages":{"status":"missing","reason":"not_collected"},"other_packages":{"status":"missing","reason":"not_classified"}},"medical":{"indications":["Biopsy-confirmed neuroblastoma","Intermediate-risk or high-risk disease needing multimodal therapy","Residual or relapsed disease after initial treatment"],"contraindications":["Severe uncontrolled infection at the start of a chemotherapy cycle","Severe organ failure that prevents chemotherapy or surgery","Pregnancy (for chemotherapy and radiotherapy)","Patient unfit for general anesthesia"],"operation_hours":{"status":"missing","reason":"not_collected"},"anesthesia":["general"],"sessions_or_stages":{"sessions":{"min":4,"max":20,"unit":"visits","qualifier":"Chemotherapy and immunotherapy cycles, varying by risk group"},"stages":[{"code":"induction","label":"Induction chemotherapy","after":{"min":0,"max":0,"unit":"days","qualifier":"Start of treatment"}},{"code":"surgery","label":"Tumor resection","after":{"min":120,"max":150,"unit":"days","qualifier":"From start of treatment, after induction"}},{"code":"consolidation","label":"High-dose chemotherapy with stem cell rescue and radiotherapy","after":{"min":150,"max":240,"unit":"days","qualifier":"From start of treatment, after surgery"}},{"code":"maintenance","label":"Immunotherapy and differentiation therapy","after":{"min":240,"max":420,"unit":"days","qualifier":"From start of treatment"}}],"qualifier":"Multimodal protocol; the number of cycles depends on risk group."},"hospital_nights":{"value":30,"source":"offers","parsed_details":{"min":60,"max":120,"unit":"nights","qualifier":"Cumulative inpatient nights across chemotherapy cycles, surgery, stem cell rescue and immunotherapy in the high-risk protocol."}},"treatment_conditions":["inpatient","outpatient"],"rehabilitation_days":{"min":30,"max":90,"unit":"days","qualifier":"Functional recovery after intensive phases; depends on surgery extent, blood count recovery and immunotherapy toxicity."},"fly_home_after_days":{"min":365,"max":540,"unit":"days","qualifier":"From treatment start; patients relocating for treatment usually travel home after immunotherapy ends and oncologist clearance."},"back_to_work_days":{"min":90,"max":600,"unit":"days","qualifier":"From treatment start; earlier for intermediate risk; depends on consolidation toxicity and job demands."},"exercise_resume_weeks":{"min":8,"max":24,"unit":"weeks","qualifier":"After completing consolidation; light activity earlier, strenuous exercise after counts, surgical healing and clearance."},"final_result_months":{"min":12,"max":18,"unit":"months","qualifier":"From treatment start to end-of-treatment imaging and marrow evaluation; depends on risk group and response."},"result_longevity":"Durable remission is possible, but relapse risk is highest in the first 2-3 years in high-risk disease. Surveillance imaging continues for several years.","main_risks":["Low blood counts and serious infections","Nausea, vomiting and mucositis","Hearing loss, kidney and heart toxicity","Surgical bleeding and nerve or organ injury","Secondary cancers and late endocrine effects"],"complication_rate_pct":{"min":60,"max":95,"unit":"percent","qualifier":"Any grade 3-4 toxicity (infection, neutropenia, mucositis) during high-risk therapy; late effects like hearing loss add."},"revision_rate_pct":{"min":30,"max":50,"unit":"percent","qualifier":"Relapse or progression needing second-line therapy in high-risk disease; lower in intermediate risk."},"success":{"metric":"5-year event-free survival, high-risk disease","value":50,"horizon":"5 years","source":{"status":"missing","reason":"not_collected"},"evidence_status":"limited"},"scars":"Surgical scar at the tumor site and a small scar from the central line; size depends on the approach.","pain":"Moderate to severe during surgery recovery, mucositis and immunotherapy; controlled with scheduled analgesia.","preparation":["Biopsy with MYCN and genetic testing","MRI or CT and MIBG scan","Bone marrow evaluation","Heart, kidney and hearing tests","Central venous line placement","Fertility preservation discussion"],"recovery_timeline":[{"phase":"Induction chemotherapy","description":"Several chemotherapy cycles over about 2-4 months, with stem cell collection in high-risk disease.","restrictions":["Avoid infection exposure","Frequent blood tests"]},{"phase":"Surgery and consolidation","description":"Tumor resection, then high-dose chemotherapy with stem cell rescue and radiotherapy where indicated.","restrictions":["Isolation during blood count recovery","No strenuous activity"]},{"phase":"Post-consolidation","description":"Immunotherapy and differentiation therapy for high-risk disease, then scheduled surveillance.","restrictions":["Stay at center for infusion monitoring"]}],"follow_up_visits":[{"purpose":"assessment","requirement":"routine","after":{"min":90,"max":120,"unit":"days","qualifier":"Response imaging and MIBG scan after induction chemotherapy"}},{"purpose":"result_review","requirement":"routine","after":{"min":365,"max":540,"unit":"days","qualifier":"End-of-treatment imaging and marrow evaluation"}}],"sources":{"status":"missing","reason":"not_collected"},"clinic_checks":{"status":"ok","items":[{"id":"C1","text":"Confirm the surgeon is trained and experienced in the exact procedure you are considering, not just in surgery generally","scope":"treatment_abroad","source":{"url":"https://www.isaps.org/discover/patients-home/considering-your-procedure-abroad/finding-a-surgeon-abroad/","host":"isaps.org","quote":"Verify that the surgeon is trained and experienced in performing the procedure you are considering.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C2","text":"Ask for certification information and the name of the body that certified the surgical setting","scope":"treatment_abroad","source":{"url":"https://www.isaps.org/discover/patients-home/considering-your-procedure-abroad/finding-a-surgeon-abroad/","host":"isaps.org","quote":"Ask for certification information and the name of the certifying body when assessing a surgical setting.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C3","text":"Check that the surgeon who consults with you is the same person who will carry out the procedure","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Check that the surgeon you consult with, will be the same person carrying out the procedure.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C4","text":"Ask whether a doctor is always present in the clinic and whether a high dependency or intensive care unit exists","scope":"treatment_abroad","source":{"url":"https://www.bapras.org.uk/public/patient-information/cosmetic-surgery/cosmetic-surgery-abroad","host":"bapras.org.uk","quote":"Is there always a doctor in the clinic and is there a high dependency or intensive care unit?","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C5","text":"Ask whether the surgeon and the facility use a surgical safety checklist, which can reduce complications","scope":"treatment_abroad","source":{"url":"https://www.isaps.org/discover/patients-home/considering-your-procedure-abroad/finding-a-surgeon-abroad/","host":"isaps.org","quote":"Do the surgeon and his/her facility use a safety checklist?","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-14","next_check_at":"2027-11-14","version":1},"red_flags":{"status":"ok","items":[{"id":"F1","text":"An advert or information that guarantees complete success should raise concerns","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Any advert or information that guarantees complete success should raise concerns.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"F2","text":"Forceful persuasion or cheap, time-limited offers pushing you into a quick decision","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Don’t be pressured into quick decisions either through forceful persuasion or cheap, time limited offers.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"F3","text":"A price that sounds too good to be true probably is","scope":"treatment_abroad","source":{"url":"https://www.plasticsurgery.org/news/articles/will-economic-uncertainty-drive-more-patients-overseas-for-plastic-surgery-what-to-consider-and-how-to-stretch-your-dollar-back-home","host":"plasticsurgery.org","quote":"If the price sounds too good to be true, it probably is.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-14","next_check_at":"2027-11-14","version":1},"warning_signs":{"status":"ok","items":[{"id":"W1","text":"Shortness of breath after stem cell infusion","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/treatments/22170-autologous-stem-cell-transplant","host":"my.clevelandclinic.org","quote":"Shortness of breath (dyspnea).","tier":"tier1_medical","fetched_at":"2026-11-13","http_status":200}},{"id":"W2","text":"Swelling of lips, tongue, or throat","urgency":"emergency","general":false,"source":{"url":"https://www.mskcc.org/cancer-care/patient-education/3f8-hu3f8-treatment","host":"mskcc.org","quote":"Your lips, tongue, or throat are swelling.","tier":"tier1_medical","fetched_at":"2026-11-13","http_status":200}},{"id":"W3","text":"Painful or frequent urination","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/treatments/22170-autologous-stem-cell-transplant","host":"my.clevelandclinic.org","quote":"Frequent urination or painful urination (dysuria).","tier":"tier1_medical","fetched_at":"2026-11-13","http_status":200}},{"id":"W4","text":"Fever of 101°F or higher","urgency":"contact_clinic","general":true,"source":{"url":"https://www.mskcc.org/cancer-care/patient-education/3f8-hu3f8-treatment","host":"mskcc.org","quote":"You have a fever of 101°F (38.3°C) or higher.","tier":"tier1_medical","fetched_at":"2026-11-13","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"take_home":{"status":"ok","items":[{"id":"T1","text":"Ask for copies of all prescriptions before you leave","document":"prescription copies","source":{"url":"https://travelhealthpro.org.uk/news/699/travelling-abroad-for-treatment","host":"travelhealthpro.org.uk","quote":"Remember to ask for copies of all your treatment records, including prescriptions, scans and x-rays before you leave.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"T2","text":"Home doctor needs the clinic's follow-up recommendations in a written discharge summary","document":"discharge summary","source":{"url":"https://sbuhb.nhs.wales/about-us/individual-patient-commissioning/ipc-folder/advice-on-accessing-treatment-abroad","host":"sbuhb.nhs.wales","quote":"When you have treatment abroad, you must ask the treatment provider for their follow-up recommendations documented within a written discharge summary in English.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"T3","text":"Home doctor needs the dates for required blood tests and follow-up appointments","document":"written aftercare plan","source":{"url":"https://sbuhb.nhs.wales/about-us/individual-patient-commissioning/ipc-folder/advice-on-accessing-treatment-abroad","host":"sbuhb.nhs.wales","quote":"This should include any medication and doses, as well as any dates that blood tests and follow-up appointments must be carried out.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-14","next_check_at":"2027-11-14","version":1}},"parsed_details":{"procedure_type":"therapy","fields":{"anesthesia":["general"],"back_to_work_days":{"min":90,"max":600,"unit":"days","qualifier":"From treatment start; earlier for intermediate risk; depends on consolidation toxicity and job demands."},"complication_rate_pct":{"min":60,"max":95,"unit":"percent","qualifier":"Any grade 3-4 toxicity (infection, neutropenia, mucositis) during high-risk therapy; late effects like hearing loss add."},"contraindications":["Severe uncontrolled infection at the start of a chemotherapy cycle","Severe organ failure that prevents chemotherapy or surgery","Pregnancy (for chemotherapy and radiotherapy)","Patient unfit for general anesthesia"],"days_in_clinic":{"min":60,"max":120,"unit":"nights","qualifier":"Cumulative inpatient nights across chemotherapy cycles, surgery, stem cell rescue and immunotherapy in the high-risk protocol."},"diagnostic_duration_minutes":null,"diagnostic_preparation":null,"diagnostic_referral_needed":null,"diagnostic_result_time_hours":null,"exercise_resume_weeks":{"min":8,"max":24,"unit":"weeks","qualifier":"After completing consolidation; light activity earlier, strenuous exercise after counts, surgical healing and clearance."},"final_result_months":{"min":12,"max":18,"unit":"months","qualifier":"From treatment start to end-of-treatment imaging and marrow evaluation; depends on risk group and response."},"fly_home_after_days":{"min":365,"max":540,"unit":"days","qualifier":"From treatment start; patients relocating for treatment usually travel home after immunotherapy ends and oncologist clearance."},"follow_up_visits":[{"purpose":"assessment","after":{"min":90,"max":120,"unit":"days","qualifier":"Response imaging and MIBG scan after induction chemotherapy"},"requirement":"routine"},{"purpose":"result_review","after":{"min":365,"max":540,"unit":"days","qualifier":"End-of-treatment imaging and marrow evaluation"},"requirement":"routine"}],"indications":["Biopsy-confirmed neuroblastoma","Intermediate-risk or high-risk disease needing multimodal therapy","Residual or relapsed disease after initial treatment"],"main_risks":["Low blood counts and serious infections","Nausea, vomiting and mucositis","Hearing loss, kidney and heart toxicity","Surgical bleeding and nerve or organ injury","Secondary cancers and late endocrine effects"],"pain":"Moderate to severe during surgery recovery, mucositis and immunotherapy; controlled with scheduled analgesia.","preparation":["Biopsy with MYCN and genetic testing","MRI or CT and MIBG scan","Bone marrow evaluation","Heart, kidney and hearing tests","Central venous line placement","Fertility preservation discussion"],"recovery_timeline":[{"phase":"Induction chemotherapy","description":"Several chemotherapy cycles over about 2-4 months, with stem cell collection in high-risk disease.","restrictions":["Avoid infection exposure","Frequent blood tests"]},{"phase":"Surgery and consolidation","description":"Tumor resection, then high-dose chemotherapy with stem cell rescue and radiotherapy where indicated.","restrictions":["Isolation during blood count recovery","No strenuous activity"]},{"phase":"Post-consolidation","description":"Immunotherapy and differentiation therapy for high-risk disease, then scheduled surveillance.","restrictions":["Stay at center for infusion monitoring"]}],"rehabilitation_days":{"min":30,"max":90,"unit":"days","qualifier":"Functional recovery after intensive phases; depends on surgery extent, blood count recovery and immunotherapy toxicity."},"result_longevity":"Durable remission is possible, but relapse risk is highest in the first 2-3 years in high-risk disease. Surveillance imaging continues for several years.","revision_rate_pct":{"min":30,"max":50,"unit":"percent","qualifier":"Relapse or progression needing second-line therapy in high-risk disease; lower in intermediate risk."},"scars":"Surgical scar at the tumor site and a small scar from the central line; size depends on the approach.","sessions_or_stages":{"qualifier":"Multimodal protocol; the number of cycles depends on risk group.","sessions":{"min":4,"max":20,"unit":"visits","qualifier":"Chemotherapy and immunotherapy cycles, varying by risk group"},"stages":[{"code":"induction","label":"Induction chemotherapy","after":{"min":0,"max":0,"unit":"days","qualifier":"Start of treatment"}},{"code":"surgery","label":"Tumor resection","after":{"min":120,"max":150,"unit":"days","qualifier":"From start of treatment, after induction"}},{"code":"consolidation","label":"High-dose chemotherapy with stem cell rescue and radiotherapy","after":{"min":150,"max":240,"unit":"days","qualifier":"From start of treatment, after surgery"}},{"code":"maintenance","label":"Immunotherapy and differentiation therapy","after":{"min":240,"max":420,"unit":"days","qualifier":"From start of treatment"}}]},"success":{"metric":"5-year event-free survival, high-risk disease","value":50,"unit":"percent","horizon":"5 years","population":"Children with high-risk neuroblastoma on multimodal protocol with anti-GD2 immunotherapy","evidence_status":"limited"},"techniques":[{"name":"Multiagent chemotherapy with surgery","suits_whom":"Intermediate-risk disease","recovery":"Several months of cycles; surgery recovery 1-3 weeks."},{"name":"High-dose chemotherapy with autologous stem cell rescue, radiotherapy and anti-GD2 immunotherapy","suits_whom":"High-risk disease","recovery":"Treatment lasts about 12-18 months."},{"name":"MIBG radionuclide therapy","suits_whom":"Relapsed or refractory MIBG-avid disease","recovery":"Short isolation after dosing; blood counts monitored."}],"treatment_conditions":["inpatient","outpatient"],"treatment_duration_hours":null,"initial_assessment_documents":["Biopsy and pathology report","MYCN and genetic test results","MRI or CT of the tumor","MIBG scan report","Bone marrow biopsy report","Latest blood test results"],"travel_trips":{"min":2,"max":4,"one_trip_possible":false,"qualifier":"Relocated for the full course; arrival, departure and any return visits."},"clinic_checks":{"status":"ok","items":[{"id":"C1","text":"Confirm the surgeon is trained and experienced in the exact procedure you are considering, not just in surgery generally","scope":"treatment_abroad","source":{"url":"https://www.isaps.org/discover/patients-home/considering-your-procedure-abroad/finding-a-surgeon-abroad/","host":"isaps.org","quote":"Verify that the surgeon is trained and experienced in performing the procedure you are considering.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C2","text":"Ask for certification information and the name of the body that certified the surgical setting","scope":"treatment_abroad","source":{"url":"https://www.isaps.org/discover/patients-home/considering-your-procedure-abroad/finding-a-surgeon-abroad/","host":"isaps.org","quote":"Ask for certification information and the name of the certifying body when assessing a surgical setting.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C3","text":"Check that the surgeon who consults with you is the same person who will carry out the procedure","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Check that the surgeon you consult with, will be the same person carrying out the procedure.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C4","text":"Ask whether a doctor is always present in the clinic and whether a high dependency or intensive care unit exists","scope":"treatment_abroad","source":{"url":"https://www.bapras.org.uk/public/patient-information/cosmetic-surgery/cosmetic-surgery-abroad","host":"bapras.org.uk","quote":"Is there always a doctor in the clinic and is there a high dependency or intensive care unit?","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C5","text":"Ask whether the surgeon and the facility use a surgical safety checklist, which can reduce complications","scope":"treatment_abroad","source":{"url":"https://www.isaps.org/discover/patients-home/considering-your-procedure-abroad/finding-a-surgeon-abroad/","host":"isaps.org","quote":"Do the surgeon and his/her facility use a safety checklist?","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-14","next_check_at":"2027-11-14","version":1},"red_flags":{"status":"ok","items":[{"id":"F1","text":"An advert or information that guarantees complete success should raise concerns","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Any advert or information that guarantees complete success should raise concerns.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"F2","text":"Forceful persuasion or cheap, time-limited offers pushing you into a quick decision","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Don’t be pressured into quick decisions either through forceful persuasion or cheap, time limited offers.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"F3","text":"A price that sounds too good to be true probably is","scope":"treatment_abroad","source":{"url":"https://www.plasticsurgery.org/news/articles/will-economic-uncertainty-drive-more-patients-overseas-for-plastic-surgery-what-to-consider-and-how-to-stretch-your-dollar-back-home","host":"plasticsurgery.org","quote":"If the price sounds too good to be true, it probably is.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-14","next_check_at":"2027-11-14","version":1},"warning_signs":{"status":"ok","items":[{"id":"W1","text":"Shortness of breath after stem cell infusion","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/treatments/22170-autologous-stem-cell-transplant","host":"my.clevelandclinic.org","quote":"Shortness of breath (dyspnea).","tier":"tier1_medical","fetched_at":"2026-11-13","http_status":200}},{"id":"W2","text":"Swelling of lips, tongue, or 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recommendations documented within a written discharge summary in English.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"T3","text":"Home doctor needs the dates for required blood tests and follow-up appointments","document":"written aftercare plan","source":{"url":"https://sbuhb.nhs.wales/about-us/individual-patient-commissioning/ipc-folder/advice-on-accessing-treatment-abroad","host":"sbuhb.nhs.wales","quote":"This should include any medication and doses, as well as any dates that blood tests and follow-up appointments must be carried out.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-14","next_check_at":"2027-11-14","version":1},"alternatives":{"status":"ok","items":[{"id":"A1","text":"The child has favorable tumor biology without signs or symptoms","name":"Observation and supportive care","source":{"url":"https://www.cancer.gov/types/neuroblastoma/patient/neuroblastoma-treatment-pdq","host":"cancer.gov","quote":"observation and supportive care for children who have favorable tumor biology and do not have signs or symptoms","tier":"tier1_medical","fetched_at":"2026-11-14","http_status":200},"operation_id":null}],"checked_at":"2026-11-14","next_check_at":"2027-11-14","version":1},"technique_details":{"status":"ok","items":[{"id":"multiagent-chemotherapy","name":"Multiagent chemotherapy with surgery","how_it_works":{"text":"Chemotherapy is given first, and surgery removes the primary tumor when possible","source":{"url":"https://www.cancer.gov/news-events/cancer-currents-blog/2019/high-risk-neuroblastoma-tandem-transplant","host":"cancer.gov","quote":"Treatment of patients with high-risk neuroblastoma begins with induction therapy, which involves multi-drug chemotherapy regimens and, when possible, surgical removal of the primary tumor.","tier":"tier1_medical","fetched_at":"2026-11-14","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"}},{"id":"high-dose-chemotherapy","name":"High-dose chemotherapy with autologous stem cell rescue, radiotherapy and anti-GD2 immunotherapy","how_it_works":{"text":"High-dose chemotherapy is followed by infusion of stored blood stem cells","source":{"url":"https://www.cancer.gov/news-events/cancer-currents-blog/2019/high-risk-neuroblastoma-tandem-transplant","host":"cancer.gov","quote":"That is followed by consolidation therapy, which involves administration of very high-dose chemotherapy and infusion of the patient’s own stored blood stem cells, known as an autologous transplant.","tier":"tier1_medical","fetched_at":"2026-11-14","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"}},{"id":"mibg-radionuclide-therapy","name":"MIBG radionuclide therapy","how_it_works":{"text":"MIBG delivers radiation directly to cancer cells","source":{"url":"https://www.cancer.gov/news-events/cancer-currents-blog/2019/high-risk-neuroblastoma-tandem-transplant","host":"cancer.gov","quote":"I 131 MIBG—which delivers radiation directly to cancer cells—is being tested as part of induction therapy.","tier":"tier1_medical","fetched_at":"2026-11-14","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"}}],"checked_at":"2026-11-14","next_check_at":"2027-11-14","version":1}}},"techniques":[{"id":"multiagent-chemotherapy","name":"Multiagent chemotherapy with surgery","how_it_works":{"id":"H1","text":"Chemotherapy is given first, and surgery removes the primary tumor when possible","source":{"url":"https://www.cancer.gov/news-events/cancer-currents-blog/2019/high-risk-neuroblastoma-tandem-transplant","host":"cancer.gov","quote":"Treatment of patients with high-risk neuroblastoma begins with induction therapy, which involves multi-drug chemotherapy regimens and, when possible, surgical removal of the primary tumor.","tier":"tier1_medical","fetched_at":"2026-11-14","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"},"suits_whom":"Intermediate-risk disease","price_from":{"status":"missing","reason":"not_collected"},"recovery":"Several months of cycles; surgery recovery 1-3 weeks."},{"id":"high-dose-chemotherapy","name":"High-dose chemotherapy with autologous stem cell rescue, radiotherapy and anti-GD2 immunotherapy","how_it_works":{"id":"H1","text":"High-dose chemotherapy is followed by infusion of stored blood stem cells","source":{"url":"https://www.cancer.gov/news-events/cancer-currents-blog/2019/high-risk-neuroblastoma-tandem-transplant","host":"cancer.gov","quote":"That is followed by consolidation therapy, which involves administration of very high-dose chemotherapy and infusion of the patient’s own stored blood stem cells, known as an autologous transplant.","tier":"tier1_medical","fetched_at":"2026-11-14","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"},"suits_whom":"High-risk disease","price_from":{"status":"missing","reason":"not_collected"},"recovery":"Treatment lasts about 12-18 months."},{"id":"mibg-radionuclide-therapy","name":"MIBG radionuclide therapy","how_it_works":{"id":"H1","text":"MIBG delivers radiation directly to cancer cells","source":{"url":"https://www.cancer.gov/news-events/cancer-currents-blog/2019/high-risk-neuroblastoma-tandem-transplant","host":"cancer.gov","quote":"I 131 MIBG—which delivers radiation directly to cancer cells—is being tested as part of induction therapy.","tier":"tier1_medical","fetched_at":"2026-11-14","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"},"suits_whom":"Relapsed or refractory MIBG-avid disease","price_from":{"status":"missing","reason":"not_collected"},"recovery":"Short isolation after dosing; blood counts monitored."}],"alternatives":{"status":"ok","items":[{"id":"A1","text":"The child has favorable tumor biology without signs or symptoms","name":"Observation and supportive care","source":{"url":"https://www.cancer.gov/types/neuroblastoma/patient/neuroblastoma-treatment-pdq","host":"cancer.gov","quote":"observation and supportive care for children who have favorable tumor biology and do not have signs or symptoms","tier":"tier1_medical","fetched_at":"2026-11-14","http_status":200},"operation_id":null}],"checked_at":"2026-11-14","next_check_at":"2027-11-14","version":1},"diagnostic":{"status":"not_applicable"},"country":{"why":{"status":"missing","reason":"no_official_source","checked_at":"2026-11-11","next_check_at":"2027-02-09"},"travel":{"status":"ok","items":[{"id":"V1","item":"visa","audience":"uk","volatile":true,"text":"British citizens can visit Israel as tourists without a visa","source":{"url":"https://www.gov.uk/foreign-travel-advice/israel/entry-requirements","host":"gov.uk","quote":"You can visit Israel without a visa as a tourist.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}},{"id":"V2","item":"passport_validity","audience":"uk","volatile":true,"text":"To enter Israel, your passport must have an expiry date at least 90 days after the date you arrive","source":{"url":"https://www.gov.uk/foreign-travel-advice/israel/entry-requirements","host":"gov.uk","quote":"To enter Israel or Palestine, your passport must have an ‘expiry date’ at least 90 days after the date you arrive.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}},{"id":"V3","item":"arrival_form","audience":"uk","volatile":true,"text":"Visitors must get an Electronic Travel Authorisation (ETA) before arriving in Israel","source":{"url":"https://www.gov.uk/foreign-travel-advice/israel/entry-requirements","host":"gov.uk","quote":"As of 1 January 2025, to visit Israel you will need to get an Electronic Travel Authorisation (ETA) before you arrive.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}},{"id":"V4","item":"hospital_payment","audience":"all","volatile":false,"text":"Hospitals in Israel insist on payment and may take legal action to stop you leaving until bills are paid","source":{"url":"https://www.gov.uk/foreign-travel-advice/israel/health","host":"gov.uk","quote":"Hospitals will insist on payment and may take legal action to stop you leaving until bills are paid.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-11","next_check_at":"2026-12-11","version":1},"other_countries_with_page":["austria","egypt","germany","india","republic-of-korea","spain","thailand","turkey"]},"often_combined_with":{"status":"missing","reason":"not_collected"},"reviews":{"avg_rating":5,"count":2,"scope":"clinic","rating_scale":5,"pros":{"status":"missing","reason":"not_collected"},"cons":{"status":"missing","reason":"not_collected"}},"current":{"seo_text":"<p>Complex treatment of neuroblastoma in Israel typically costs from _op_409_price_from_ to _op_409_price_to_. The total price depends on the disease stage, risk category, and specific therapies like MIBG or stem cell transplants. In the US, this procedure costs _price_compare_US_average_ on average. Most Israeli medical programs include comprehensive diagnostics, personalized treatment protocols, and inpatient care in specialized pediatric oncology units.</p>\n\n<ul>\n<li><strong>Diagnostic evaluation.</strong> Staging involves blood panels, imaging, and bone marrow biopsies to determine risk levels.</li>\n<li><strong>Surgical resection.</strong> Costs vary by tumor location and the need for specialized neurosurgical or pediatric surgical teams.</li>\n<li><strong>Stem cell transplantation.</strong> Autologous bone marrow transplants require intensive isolation and approximately 30 days of inpatient monitoring.</li>\n<li><strong>Advanced immunotherapies.</strong> Protocols may include anti-GD2 antibody therapy or CAR-T cell manufacturing for high-risk cases.</li>\n</ul>\n\n<p><strong>Bookimed Expert Insight.</strong> Israeli centers like Sheba Medical Center offer high-value access to advanced technologies like MIBG therapy and in-house CAR-T manufacturing. Sheba is ranked among the world's top 10 hospitals and handles 9,000 pediatric cases annually. Specialists like Dr. Ronit El Hasid at Sourasky Medical Center have performed over 300 successful transplantations. Choosing JCI-accredited facilities in Tel Aviv or Ramat Gan ensures access to doctors often listed in Forbes' Top Doctors. These institutions provide integrated care where surgical oncology, immunotherapy, and bone marrow transplants are managed on a single campus.</p>","faq":[{"q":"Why is Israel a top destination for neurosurgery?","a":"<p>Israel is a premier neurosurgery hub due to its fusion of high-density medical innovation and elite surgical expertise. Top facilities like Sheba Medical Center integrate AI-guided navigation and real-time intraoperative MRI. Specialized centers report 98% success rates for complex procedures including awake craniotomy and movement disorder treatments.</p> <ul> <li><strong>Advanced technology:</strong> Clinics utilize MRI-guided focused ultrasound (MRgFUS) and robotic systems for incisions.</li> <li><strong>Surgical expertise:</strong> Surgeons like Dr. Zvi Ram lead international associations with 25+ years experience.</li> <li><strong>Rapid access:</strong> International patients typically schedule complex brain or spine surgeries within 2–4 weeks.</li> <li><strong>Accredited care:</strong> Major centers like Sourasky (Ichilov) and Assuta hold JCI accreditation for safety.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Data shows a clear divide between public and private options in Israel. Private centers like Assuta Medical Center perform over 92,000 operations annually and allow patients to select their specific lead surgeon. This is a vital advantage for complex cases where a specific expert like Dr. Eli Ashkenazi is preferred for his 1,000+ spine surgery record.</p> <p><strong>Patient Consensus:</strong> Patients emphasize bringing original imaging on a USB for local review to streamline the surgical plan. They also note that private packages often include hotel coordination and airport transfers, making the logistics much smoother.</p>"},{"q":"What types of neurosurgical conditions are treated in Israel?","a":"<p>Israeli neurosurgeons treat a full spectrum of conditions ranging from brain and spinal tumors to complex functional disorders. Specialized centers utilize advanced technologies like Gamma Knife, deep brain stimulation, and intraoperative MRI to manage epilepsy, Parkinson disease, and cerebrovascular pathologies with high precision.</p> <ul> <li><strong>Oncological conditions:</strong> Treatment for gliomas, meningiomas, and pituitary tumors using skull base resection.</li> <li><strong>Functional disorders:</strong> Management of Parkinson disease and essential tremors via deep brain stimulation.</li> <li><strong>Spinal pathologies:</strong> Correction of scoliosis, herniated discs, and spinal tumors using robotic systems.</li> <li><strong>Cerebrovascular care:</strong> Surgical repair of brain aneurysms and arteriovenous malformations with endovascular interventions.</li> <li><strong>Pediatric neurosurgery:</strong> Specialized care for hydrocephalus and congenital anomalies at dedicated children centers.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Israeli hospitals often combine specialties to handle complex cases. At Sourasky Medical Center, neurosurgeons like Dr. Zvi Lidar bridge neurosurgery and orthopedics for spinal care. This multidisciplinary approach allows clinics to perform 34,000+ operations annually. Choosing a facility with this crossover expertise often leads to more comprehensive treatment plans for degenerative diseases.</p> <p><strong>Patient Consensus:</strong> Patients value the ability to access specialized treatments like fluorescence-guided surgery for tumors which are often unavailable elsewhere. Many note that the staff is fluent in English and provides clear communication through teleconsultations before traveling.</p>"},{"q":"Which hospitals in Israel are best known for neurosurgery?","a":"<p>Israel is home to world-renowned neurosurgery centers like Sourasky Medical Center, Sheba Medical Center, and Hadassah Medical Center. These facilities are globally ranked for treating complex brain tumors, spinal disorders, and movement diseases. They utilize advanced technologies like Gamma Knife, robotic systems, and intra-operative MRI.</p> <ul> <li><strong>Sourasky (Ichilov):</strong> Performs 2,500+ neurosurgical operations yearly with a 98% success rate in Tel Aviv.</li> <li><strong>Sheba Medical Center:</strong> Ranked among the world's top 10 hospitals. It treats 1.9 million patients annually.</li> <li><strong>Hadassah Medical Center:</strong> A Nobel Peace Prize nominee. It leads in pediatric neurosurgery and gene-based therapies.</li> <li><strong>Assuta Medical Center:</strong> Israel's largest private facility. It specializes in minimally invasive spine and brain surgeries.</li> <li><strong>Schneider Children's:</strong> The primary center for pediatric neurosurgery. It treats 275,000 children every year.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Our data shows that while most patients focus on Tel Aviv, Rambam Medical Center in Haifa offers unique expertise in neuro-trauma. It operates a specialized neuro-ICU and serves nearly 1 million patients annually. This makes it an essential choice for complex post-trauma brain surgeries that requires intensive recovery support.</p> <p><strong>Patient Consensus:</strong> Patients note it is important to start consultations early. They often highlight that the precision and follow-up care for complex brain tumors exceeded their expectations. One patient emphasized how quickly they could connect with top professors for second opinions during critical neurosurgical cases.</p>"},{"q":"Who are Israel’s leading neurosurgeons?","a":"<p>Israel's leading neurosurgeons include Prof. Zvi Ram, Prof. Shlomi Constantini, and Prof. Itzhak Fried at Sourasky Medical Center. These specialists hold leadership roles in the European Association of Neurosurgical Societies (EANS) and the World Society for Stereotactic and Functional Neurosurgery (WSSFN). They utilize advanced intraoperative mapping and robotic systems.</p> <ul> <li><strong>Prof. Zvi Ram:</strong> Expert in minimally invasive brain tumor surgery and gene-based oncology therapies.</li> <li><strong>Prof. Shlomi Constantini:</strong> Specializes in complex pediatric neuro-endoscopy and brain tumor microsurgery.</li> <li><strong>Prof. Itzhak Fried:</strong> Authority on epilepsy surgery, functional brain mapping, and deep brain stimulation.</li> <li><strong>Dr. Eli Ashkenazi:</strong> Leading spine surgeon at Assuta, specializing in the innovative TOPS system.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Data from Sourasky and Sheba indicates a strong correlation between high surgical volumes and patient safety. For example, Sourasky performs 34,000+ operations annually with a 90% oncology success rate. Patients seeking complex tumor removals should prioritize centers like these where surgeons perform hundreds of specific cases each year.</p> <p><strong>Patient Consensus:</strong> Patients emphasize the importance of finding a surgeon who specializes specifically in your condition rather than a generalist. Many note that high-volume centers provide better access to English-speaking staff and coordinated care for international visitors.</p>"},{"q":"What are the admission requirements for international neurosurgery patients?","a":"<p>International neurosurgery patients in Israel must provide comprehensive medical records including recent MRI or CT scans translated into English. Admission requires a clinical review by specialists to confirm treatment feasibility. Hospitals often mandate full advance payment or a significant deposit before confirming surgery dates or issuing visa support letters.</p> <ul> <li><strong>Medical documentation:</strong> Submit detailed English-translated reports and imaging for clinical review within 48 hours.</li> <li><strong>Financial clearance:</strong> Provide proof of funds for approximately _price_from_ to _price_to_ for treatment.</li> <li><strong>Visa support:</strong> Clinics like Sourasky Medical Center (Ichilov) issue official letters for medical B-2 visas.</li> <li><strong>Consultation phase:</strong> Initial assessment often occurs via online consultation with surgeons like Dr. Strauss Ido.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Data shows that top Israeli facilities like Sheba Medical Center and Hadassah Medical Center handle massive patient volumes, exceeding 1,000,000 people annually. This high demand means clinics prioritize complex or rare cases over routine procedures. Patients with unique or high-risk conditions often receive faster admission approval than those seeking standard treatments available elsewhere.</p> <p><strong>Patient Consensus:</strong> Patients note that having all imaging results ready in English is essential for quick scheduling. Many emphasize that while the medical care is excellent, coordinating around Shabbat closures is necessary to avoid unexpected diagnostic delays.</p>"},{"q":"How long will I need to stay in Israel for neurosurgery and follow-up?","a":"<p>A standard stay for neurosurgery in Israel ranges from 10 to 14 days for uncomplicated cases. Patients undergoing complex procedures like brain tumor removal or deep brain stimulation often require 4 to 6 weeks. This timeline covers pre-operative diagnostics, the surgical procedure, and essential post-operative monitoring.</p> <ul> <li><strong>Hospitalization duration:</strong> Minimally invasive procedures require 1–3 days. Regular craniotomies average 3–10 days.</li> <li><strong>Local recovery:</strong> Stay in Israel for 7–14 days post-discharge for mandatory follow-up checks.</li> <li><strong>Flight safety:</strong> Surgeons recommend waiting 4–6 weeks before flying to stabilize internal head pressure.</li> <li><strong>Follow-up schedule:</strong> In-person clinical reviews typically occur at days 3, 7, and 14 post-surgery.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Data from Sourasky Medical Center shows they treat over 400,000 patients annually with high success rates. Clinics with such high volumes, like Hadassah or Assuta, often have streamlined discharge protocols. This helps international patients transition to hotel-based recovery faster while maintaining access to top specialists.</p> <p><strong>Patient Consensus:</strong> Patients note it is vital not to rush home too early. Some travelers extended their stay to 3 weeks due to swelling or to ensure they received final surgeon clearance before flying.</p>"},{"q":"What advanced technologies make Israeli neurosurgery minimally invasive?","a":"<p>Israeli neurosurgery uses robotic guidance, real-time 3D imaging, and incisionless technologies to minimize physical trauma. Systems like Mazor Robotics provide sub-millimeter precision for spine implants. MRI-guided focused ultrasound (MRgFUS) treats tremors without incisions. These advanced tools ensure high accuracy and reduce recovery times.</p> <ul> <li><strong>Robotic systems:</strong> Mazor and ROSA robotics enable precise instrument placement through tiny incisions.</li> <li><strong>Incisionless ultrasound:</strong> MRgFUS uses high-intensity sound waves to treat brain tissue without anesthesia.</li> <li><strong>Digital navigation:</strong> Intraoperative MRI and 3D mapping allow surgeons to verify results in real-time.</li> <li><strong>Advanced endoscopy:</strong> Transnasal and trans-orbital approaches remove tumors without traditional skull-opening craniotomies.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Israeli clinics like Sourasky or Hadassah integrate proprietary Israeli-born technologies like Surgical Theater before they hit global markets. Our data shows these centers often use VR flight-through models for pre-surgical planning. This allows surgeons to rehearse complex cases, which is a key factor in their 90% success rates.</p> <p><strong>Patient Consensus:</strong> Patients note that technologies like the Gamma Knife allowed them to return home in days rather than weeks. Many move from traditional 10cm incisions to cuts under 2cm when using robotic-assisted systems.</p>"},{"q":"Why is Israel considered a top destination for neurosurgery?","a":"<p>Israel is a global leader in neurosurgery due to its integration of proprietary medical innovations and internationally trained specialists. High-capacity centers like Sourasky Medical Center (Ichilov) perform over 34,000 annual surgeries. Patients access advanced techniques like awake craniotomy and MR-guided focused ultrasound.</p> <ul> <li><strong>Advanced technology:</strong> Facilities use CyberKnife, Gamma Knife, and robotic systems for precision.</li> <li><strong>Expert credentials:</strong> Specialists like Dr. Zvi Ram hold leadership roles in European neurosurgical societies.</li> <li><strong>Global training:</strong> Most senior neurosurgeons completed fellowships at premier United States and European institutions.</li> <li><strong>Specialized departments:</strong> Centers feature niche units for pediatric neurosurgery, skull base, and functional disorders.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Israeli neurosurgery stands out because of the high concentration of dually certified experts. Many top surgeons, such as Dr. Zvi Lidar, are certified to practice in both Israel and the USA. This ensures that patients receive American-standard surgical care while staying in Tel Aviv or Jerusalem. Our data shows that private centers like Assuta offer significantly faster access to these specific specialists compared to the public system.</p> <p><strong>Patient Consensus:</strong> Patients note it is important to confirm a surgeon's specific volume of cases for your exact condition. They also value the ability to get expert second opinions quickly through online consultations with world-renowned professors.</p>"},{"q":"Which hospitals are ranked among the best for neurosurgery in Israel?","a":"<p>Sheba Medical Center and Sourasky Medical Center (Ichilov) are among the best neurosurgery hospitals in Israel. These JCI-accredited facilities perform thousands of operations annually. They utilize advanced technologies like CyberKnife and intraoperative MRI to treat complex brain tumors and cerebrovascular lesions.</p> <ul> <li><strong>Sheba Medical Center:</strong> Ranked among the top 10 world hospitals by Newsweek magazine.</li> <li><strong>Sourasky (Ichilov):</strong> Reports a 98% success rate and performs 2,500+ neurosurgical operations annually.</li> <li><strong>Hadassah Medical Center:</strong> Known for pioneering endoscopic techniques and integrated advanced research programs.</li> <li><strong>Assuta Medical Center:</strong> Israel largest private facility specializing in minimally invasive spine procedures.</li> <li><strong>Rambam Medical Center:</strong> Employs Nobel Prize laureates and serves as a major referral center.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Our data shows that top Israeli centers like Sourasky and Hadassah perform over 40,000 total operations yearly. This high volume allows surgeons to maintain a 90% success rate even in complex oncology cases. Patients seeking robotic spine surgery or deep brain stimulation should focus on these high-capacity municipal centers for the most experienced teams.</p> <p><strong>Patient Consensus:</strong> Patients appreciate that some hospitals quickly coordinate consultations even during regional strikes. Families of pediatric patients especially value surgeons trained at prestigious international institutions.</p>"},{"q":"Who are the leading neurosurgeons in Israel?","a":"<p>Israel's leading neurosurgeons include Professor Zvi Ram, Professor Shlomi Constantini, and Professor Itzhak Fried at Sourasky Medical Center. These experts specialize in awake craniotomy, pediatric brain tumors, and functional mapping. Most hold JCI accreditation and international fellowships from institutions like Johns Hopkins and Yale.</p> <ul> <li><strong>Brain tumors:</strong> Professor Zvi Ram specializes in image-guided microsurgery and complex brain mapping techniques.</li> <li><strong>Pediatric expertise:</strong> Professor Shlomi Constantini leads pediatric neurosurgery, focusing on endoscopic treatments and malformations.</li> <li><strong>Functional surgery:</strong> Professor Itzhak Fried is a global authority on epilepsy and deep brain stimulation.</li> <li><strong>Spine specialists:</strong> Dr. Zvi Lidar and Dr. Eli Ashkenazi focus on minimally invasive spinal oncology.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Data shows that top-tier Israeli neurosurgeons, such as those at Sourasky Medical Center, often hold dual board certifications in Israel and the US. This unique crossover ensures patients receive American-standard protocols. These specialists typically manage over 34,000 annual operations, providing high-volume clinical experience that smaller private clinics cannot match.</p> <p><strong>Patient Consensus:</strong> Patients note that highly qualified doctors like Professor Shlomo Constantini provide satisfactory answers quickly. People emphasize that outcomes often depend on the hospital’s integrated resources rather than just a doctor's prestige.</p>"},{"q":"What neurosurgical conditions and sub-specialties are treated in Israel?","a":"<p>Israel is a global leader in neurosurgery, treating complex brain and spinal conditions using robotic-assisted and minimally invasive techniques. Highly specialized units at JCI-accredited centers like Sourasky Medical Center (Ichilov) and Hadassah Medical Center focus on neuro-oncology, pediatric neurosurgery, and functional procedures.</p> <ul> <li><strong>Neuro-oncology:</strong> Treating glioblastoma, meningioma, and skull base tumors with 90% success rates.</li> <li><strong>Functional neurosurgery:</strong> Performing deep brain stimulation (DBS) for Parkinson’s and drug-resistant epilepsy.</li> <li><strong>Pediatric specialty:</strong> Specialized care for congenital defects and childhood tumors at Schneider Children’s.</li> <li><strong>Spine surgery:</strong> Utilizing Mazor X robotic systems for scoliosis and herniated disc correction.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Israeli neurosurgical departments often function as rapid-response hubs for international patients. Data shows that large centers like Sourasky, which serves 1,800,000 patients annually, can organize expert video consultations in a very short time. This speed is critical for neuro-oncology cases where starting treatment a few days earlier significantly impacts outcomes.</p> <p><strong>Patient Consensus:</strong> Patients note that Israeli teams often accept high-risk cases that other hospitals decline. They emphasize the importance of using local coordinators to manage travel logistics or potential local disruptions during their two-week stay.</p>"},{"q":"What documentation do international patients need before traveling to Israel for neurosurgery?","a":"<p>International patients traveling to Israel for neurosurgery require a valid passport, an entry permit or medical visa, and a formal hospital invitation. You must provide recent MRI or CT scans in DICOM format and detailed medical summaries. Proof of private health insurance and financial stability are also mandatory for border entry.</p> <ul> <li><strong>Travel authorization:</strong> Most visa-exempt travelers now need an approved ETA-IL before departure.</li> <li><strong>Hospital invitation:</strong> A signed letter from facilities like Sourasky Medical Center is required.</li> <li><strong>Medical records:</strong> Provide updated summaries of diagnoses, medications, and previous neurological treatments.</li> <li><strong>Imaging files:</strong> Digital copies of scans are essential for planning complex brain surgeries.</li> <li><strong>Legal consent:</strong> Notarized power of attorney is required for patients under 18 years old.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Our data shows that top neurosurgeons at Hadassah Medical Center and Sourasky often request records 4–6 weeks before arrival. Submitting these early prevents appointment shifts. High-volume centers with over 30,000 annual operations have dedicated portals for secure DICOM file uploads. Using these ensures your surgeon reviews high-quality images before you land in Tel Aviv.</p> <p><strong>Patient Consensus:</strong> Patients emphasize bringing physical copies and digital backups of all scans on a USB drive. They also note that private insurance needs pre-authorization specifically for neurosurgery to avoid payment delays at the clinic.</p>"}],"h2":[{"text":"Quel est le Coût pour votre Traitement complexe du neuroblastome en Israël ?","kind":"content"},{"text":"Vos avantages et garanties avec Bookimed","kind":"content"},{"text":"Votre coordinateur médical personnel","kind":"content"},{"text":"Ne Manquez pas les Offres Exclusives de traitement complexe du neuroblastome en Israël en novembre 2026","kind":"content"},{"text":"Découvrez les Meilleures Cliniques pour Votre Traitement complexe du neuroblastome en Israël : 1 Options Vérifiées et Prix","kind":"content"},{"text":"Aperçu de traitement complexe du neuroblastome en Israël","kind":"content"},{"text":"Obtenez une évaluation médicale pour Traitement complexe du neuroblastome en Israël : Choisissez le meilleur spécialiste dans le domaine","kind":"content"},{"text":"Histoires vidéo des patients de Bookimed","kind":"content"},{"text":"Partager ce contenu","kind":"content"},{"text":"FAQ de traitement complexe du neuroblastome en Israël","kind":"content"},{"text":"Obtenez une consultation gratuite","kind":"content"}]},"placeholders":{"price_from":"{{price_from}}","clinics_count":"{{clinics_count}}","cities_count":"{{cities_count}}","savings_pct":"{{savings_pct}}","data_date":"{{data_date}}"},"legal":{"restricted_markets":{"status":"missing","reason":"not_collected"}},"conflicts":[{"field":"medical.hospital_nights","chosen":"offers","offers":30,"parsed_details":{"min":60,"max":120}}]}